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Article

Structure of the monomeric 8-kDa dynein light chain and mechanism of the domain-swapped dimer assembly.

The Journal of biological chemistry - 17 Oct 2003

Wang Wenning, Lo Kevin W-H, Kan Ho-Man, Fan Jing-Song, Zhang Mingjie

Abstract excerpt

The 8-kDa light chain of dynein (DLC8) is ubiquitously expressed in various cell types. Other than serving as a light chain of the dynein complexes, this highly conserved protein has been shown to bind a larger number of proteins with diverse biological functions. DLC8 forms a homodimer via three-dimensional domain swapping of an internal beta-strand (the beta2-strand) at neutral pH. The protein undergoes...

Topics

Animals
Cytoplasmic Dyneins
Dimerization
Dyneins
Glutathione Transferase
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Models, Molecular
Mutation
Protein Conformation
Protein Structure, Secondary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Tertiary

Rats

Recombinant Proteins

Source

Identifiers

PMID: 12904292
DOI: 10.1074/jbc.M307118200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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