Article
Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy.
Nature communications - 1 May 2018
Shiloh Ruth, Gilad Yuval, Ber Yaara, Eisenstein Miriam, Aweida Dina, Bialik Shani, Cohen Shenhav, Kimchi Adi
Abstract excerpt
Autophagy is an intracellular degradation process essential for adaptation to metabolic stress. DAPK2 is a calmodulin-regulated protein kinase, which has been implicated in autophagy regulation, though the mechanism is unclear. Here, we show that the central metabolic sensor, AMPK, phosphorylates DAPK2 at a critical site in the protein structure, between the catalytic and the calmodulin-binding domains. This...
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