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Article

The association of AMPK with ULK1 regulates autophagy.

PloS one - 3 Nov 2010

Lee Jong Woo, Park Sungman, Takahashi Yoshinori, Wang Hong-Gang

Abstract excerpt

Autophagy is a highly orchestrated intracellular bulk degradation process that is activated by various environmental stresses. The serine/threonine kinase ULK1, like its yeast homologue Atg1, is a key initiator of autophagy that is negatively regulated by the mTOR kinase. However, the molecular mechanism that controls the inhibitory effect of mTOR on ULK1-mediated autophagy is not fully understood. Here we...

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Source

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Identifiers

PMID: 21072212
DOI: 10.1371/journal.pone.0015394
PMCID: PMC2972217

Genes

ULK1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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