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Article

Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase.

Oncogene - 9 Feb 2012

Mor I, Carlessi R, Ast T, Feinstein E, Kimchi A

Abstract excerpt

Death-associated protein kinase (DAPk), a multi-domain serine/threonine kinase, regulates numerous cell death mechanisms and harbors tumor suppressor functions. In this study, we report that DAPk directly binds and functionally activates pyruvate kinase M2 (PKM2), a key glycolytic enzyme, which contributes to the regulation of cancer cell metabolism. PKM2 was identified as a novel binding partner of DAPk by a...

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Identifiers

PMID: 21725354
DOI: 10.1038/onc.2011.264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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