Article

Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK

2021-03-10

Abstract excerpt

The AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, with deregulation leading to cancer and other diseases. When intracellular ATP levels decrease during energy stress, AMPK is phosphorylated and activated through AMP binding. However, how this pathway is dysregulated in cancer remains unclear. Here, we find that tumor protein D52 (TPD52), initially identified to be overexpressed...

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Literature Corpus work: dc1c4d68-d2fd-52a5-95ef-4b25e94e005b
DOI: 10.1101/2021.03.09.434668

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