Article
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis.
Nature - 18 Jan 2012
He Congcong, Bassik Michael C, Moresi Viviana, Sun Kai, Wei Yongjie, Zou Zhongju, An Zhenyi, Loh Joy, Fisher Jill, Sun Qihua, Korsmeyer Stanley, Packer Milton, May Herman I, Hill Joseph A, Virgin Herbert W, Gilpin Christopher, Xiao Guanghua, Bassel-Duby Rhonda, Scherer Philipp E, Levine Beth
Abstract excerpt
Exercise has beneficial effects on human health, including protection against metabolic disorders such as diabetes. However, the cellular mechanisms underlying these effects are incompletely understood. The lysosomal degradation pathway, autophagy, is an intracellular recycling system that functions during basal conditions in organelle and protein quality control. During stress, increased levels of autophagy...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.