Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AMPK regulates autophagy by phosphorylating BECN1 at threonine 388.

Autophagy - 1 Sept 2016

Zhang Deyi, Wang Wei, Sun Xiujie, Xu Daqian, Wang Chenyao, Zhang Qian, Wang Huafei, Luo Wenwen, Chen Yan, Chen Huaiyong, Liu Zhixue

Abstract excerpt

Macroautophagy/autophagy is a conserved catabolic process that recycles cytoplasmic material during low energy conditions. BECN1/Beclin1 (Beclin 1, autophagy related) is an essential protein for function of the class 3 phosphatidylinositol 3-kinase (PtdIns3K) complexes that play a key role in autophagy nucleation and elongation. Here, we show that AMP-activated protein kinase (AMPK) regulates autophagy by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to Apoptosis Regulatory Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autophagy

Share to Beclin-1

Share to Hep G2 Cells

Share to Phosphatidylinositol Phosphates

Share to Protein Multimerization

Share to Threonine

Source

Open in PubMed Open full text

Identifiers

PMID: 27304906
DOI: 10.1080/15548627.2016.1185576
PMCID: PMC5082788

Genes

BECN1
ATG14
BCL2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AMPK regulates autophagy by phosphorylating BECN1 at threonine 388.PMID 27304906Read ↗

The association of AMPK with ULK1 regulates autophagy.Semantic proximity Read ↗

Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy.Semantic proximity Read ↗

The beclin 1 interactome: Modification and roles in the pathology of autophagy-related disordersSemantic proximity Read ↗

Beclin1: A role in membrane dynamics and beyondSemantic proximity Read ↗

GABARAPs and LC3s have opposite roles in regulating ULK1 for autophagy inductionSemantic proximity Read ↗

Beclin 1 Biology and its Role in Heart DiseaseSemantic proximity Read ↗

AMP-activated protein kinase – not just an energy sensorSemantic proximity Read ↗

Acetylation in the regulation of autophagySemantic proximity Read ↗

The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy.Semantic proximity Read ↗

PRKAA/AMPKα phosphorylation switches the role of RASAL2 from a suppressor to an activator of autophagySemantic proximity Read ↗

The Biological Role and Clinical Significance of BECLIN-1 in CancerSemantic proximity Read ↗

Oncogenic MAGEA-TRIM28 ubiquitin ligase downregulates autophagy by ubiquitinating and degrading AMPK in cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.