Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Co-optation of Tandem DNA Repeats for the Maintenance of Mesenchymal Identity.

Cell - 17 May 2018

Balestrieri Chiara, Alfarano Gabriele, Milan Marta, Tosi Valentina, Prosperini Elena, Nicoli Paola, Palamidessi Andrea, Scita Giorgio, Diaferia Giuseppe R, Natoli Gioacchino

Abstract excerpt

Tandem repeats (TRs) are generated by DNA replication errors and retain a high level of instability, which in principle would make them unsuitable for integration into gene regulatory networks. However, the appearance of DNA sequence motifs recognized by transcription factors may turn TRs into functional cis-regulatory elements, thus favoring their stabilization in genomes. Here, we show that, in human cells, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Tandem Repeat Sequences
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromatin Immunoprecipitation

Share to Mesenchymal Stem Cells

Share to Mice, Nude

Share to MicroRNAs

Share to Mouth Mucosa

Share to Zinc Finger E-box-Binding Homeobox 1

Source

Identifiers

PMID: 29706544
DOI: 10.1016/j.cell.2018.03.081

Genes

ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Co-optation of Tandem DNA Repeats for the Maintenance of Mesenchymal Identity.PMID 29706544Read ↗

ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-driven transcriptionSemantic proximity Read ↗

Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.Semantic proximity Read ↗

ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-dependent transcriptionSemantic proximity Read ↗

Co-opted transposons help perpetuate conserved higher-order chromosomal structuresSemantic proximity Read ↗

Genetic elements promote retention of extrachromosomal DNA in cancer cellsSemantic proximity Read ↗

Epithelial–Mesenchymal Transition and Tumor Suppression Are Controlled by a Reciprocal Feedback Loop between ZEB1 and Grainyhead-like-2Semantic proximity Read ↗

The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer.Semantic proximity Read ↗

The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and metastasis-related processes through ZEB1/2Semantic proximity Read ↗

Paralogous lncRNAs CYTOR and MORRBID share a conserved trans acting function in MEK ERK signalingSemantic proximity Read ↗

Endogenous retroviruses drive KRAB zinc-finger family protein expression for tumor suppressionSemantic proximity Read ↗

Syntenic lncRNAs exhibit DNA regulatory functions with sequence evolutionSemantic proximity Read ↗

ZMYM2 controls human transposable element transcription through distinct co-regulatory complexesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.