Article

The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and metastasis-related processes through ZEB1/2

2020-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Thyroid hormone receptor interactor 12 (TRIP12) is an E3 ligase most notably involved in the proteolytic degradation of the tumor suppressor p14ARF. Through this process, it is proposed that TRIP12 plays an oncogenic role in tumor initiation and growth. However, its role in other cancer processes such as metastasis is unknown. In this study, using publicly available cancer patient datasets, we f...

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Literature Corpus work: b9450d39-6e5e-5835-8ec5-4944ef8493e5
DOI: 10.1101/2020.11.04.368209

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