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Article

Chromatin organization in myelodysplastic syndrome.

Experimental hematology - 1 Jun 2024

Xu Jane Jialu, Viny Aaron D

Abstract excerpt

Disordered chromatin organization has emerged as a new aspect of the pathogenesis of myelodysplastic syndrome (MDS). Characterized by lineage dysplasia and a high transformation rate to acute myeloid leukemia (AML), the genetic determinant of MDS is thought to be the main driver of the disease's progression. Among the recurrently mutated pathways, alterations in chromatin organization, such as the cohesin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38582293
DOI: 10.1016/j.exphem.2024.104216
PMCID: PMC11152986

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