Article
Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans.
Genetic epidemiology - 1 Sept 2018
Keaton Jacob M, Gao Chuan, Guan Meijian, Hellwege Jacklyn N, Palmer Nicholette D, Pankow James S, Fornage Myriam, Wilson James G, Correa Adolfo, Rasmussen-Torvik Laura J, Rotter Jerome I, Chen Yii-Der I, Taylor Kent D, Rich Stephen S, Wagenknecht Lynne E, Freedman Barry I, Ng Maggie C Y, Bowden Donald W
Abstract excerpt
Although type 2 diabetes (T2D) results from metabolic defects in insulin secretion and insulin sensitivity, most of the genetic risk loci identified to date relates to insulin secretion. We reported that T2D loci influencing insulin sensitivity may be identified through interactions with insulin secretion loci, thereby leading to T2D. Here, we hypothesize that joint testing of variant main effects and interaction...
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