Article
Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.
Diabetes - 1 May 2015
Palmer Nicholette D, Goodarzi Mark O, Langefeld Carl D, Wang Nan, Guo Xiuqing, Taylor Kent D, Fingerlin Tasha E, Norris Jill M, Buchanan Thomas A, Xiang Anny H, Haritunians Talin, Ziegler Julie T, Williams Adrienne H, Stefanovski Darko, Cui Jinrui, Mackay Adrienne W, Henkin Leora F, Bergman Richard N, Gao Xiaoyi, Gauderman James, Varma Rohit, Hanis Craig L, Cox Nancy J, Highland Heather M, Below Jennifer E, Williams Amy L, Burtt Noel P, Aguilar-Salinas Carlos A, Huerta-Chagoya Alicia, Gonzalez-Villalpando Clicerio, Orozco Lorena, Haiman Christopher A, Tsai Michael Y, Johnson W Craig, Yao Jie, Rasmussen-Torvik Laura, Pankow James, Snively Beverly, Jackson Rebecca D, Liu Simin, Nadler Jerry L, Kandeel Fouad, Chen Yii-Der I, Bowden Donald W, Rich Stephen S, Raffel Leslie J, Rotter Jerome I, Watanabe Richard M, Wagenknecht Lynne E
Abstract excerpt
Insulin sensitivity, insulin secretion, insulin clearance, and glucose effectiveness exhibit strong genetic components, although few studies have examined their genetic architecture or influence on type 2 diabetes (T2D) risk. We hypothesized that loci affecting variation in these quantitative traits influence T2D. We completed a multicohort genome-wide association study to search for loci influencing T2D-related...
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