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Article

Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans.

PloS one - 1 Jan 2016

Keaton Jacob M, Hellwege Jacklyn N, Ng Maggie C Y, Palmer Nicholette D, Pankow James S, Fornage Myriam, Wilson James G, Correa Adolfo, Rasmussen-Torvik Laura J, Rotter Jerome I, Chen Yii-Der I, Taylor Kent D, Rich Stephen S, Wagenknecht Lynne E, Freedman Barry I, Bowden Donald W

Abstract excerpt

Type 2 diabetes (T2D) is the result of metabolic defects in insulin secretion and insulin sensitivity, yet most T2D loci identified to date influence insulin secretion. We hypothesized that T2D loci, particularly those affecting insulin sensitivity, can be identified through interaction with insulin secretion loci. To test this hypothesis, single nucleotide polymorphisms (SNPs) associated with acute insulin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Epistasis, Genetic

Share to Insulin

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Source

Open in PubMed Open full text

Identifiers

PMID: 27448167
DOI: 10.1371/journal.pone.0159977
PMCID: PMC4957757

Genes

CHN2
EXOC1
LYPLAL1
UTRN

Provenance

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