Article
G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.
Diabetes - 1 Jun 2009
Sparsø Thomas, Bonnefond Amélie, Andersson Ehm, Bouatia-Naji Nabila, Holmkvist Johan, Wegner Lise, Grarup Niels, Gjesing Anette P, Banasik Karina, Cavalcanti-Proença Christine, Marchand Marion, Vaxillaire Martine, Charpentier Guillaume, Jarvelin Marjo-Riitta, Tichet Jean, Balkau Beverley, Marre Michel, Lévy-Marchal Claire, Faerch Kristine, Borch-Johnsen Knut, Jørgensen Torben, Madsbad Sten, Poulsen Pernille, Vaag Allan, Dina Christian, Hansen Torben, Pedersen Oluf, Froguel Philippe
Abstract excerpt
OBJECTIVE: Genome-wide association studies have identified several variants within the MTNR1B locus that are associated with fasting plasma glucose (FPG) and type 2 diabetes. We refined the association signal by direct genotyping and examined for associations of the variant displaying the most independent effect on FPG with isolated impaired fasting glycemia (i-IFG), isolated impaired glucose tolerance (i-IGT),...
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