Article
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.
Diabetes - 1 May 2010
Ingelsson Erik, Langenberg Claudia, Hivert Marie-France, Prokopenko Inga, Lyssenko Valeriya, Dupuis Josée, Mägi Reedik, Sharp Stephen, Jackson Anne U, Assimes Themistocles L, Shrader Peter, Knowles Joshua W, Zethelius Björn, Abbasi Fahim A, Bergman Richard N, Bergmann Antje, Berne Christian, Boehnke Michael, Bonnycastle Lori L, Bornstein Stefan R, Buchanan Thomas A, Bumpstead Suzannah J, Böttcher Yvonne, Chines Peter, Collins Francis S, Cooper Cyrus C, Dennison Elaine M, Erdos Michael R, Ferrannini Ele, Fox Caroline S, Graessler Jürgen, Hao Ke, Isomaa Bo, Jameson Karen A, Kovacs Peter, Kuusisto Johanna, Laakso Markku, Ladenvall Claes, Mohlke Karen L, Morken Mario A, Narisu Narisu, Nathan David M, Pascoe Laura, Payne Felicity, Petrie John R, Sayer Avan A, Schwarz Peter E H, Scott Laura J, Stringham Heather M, Stumvoll Michael, Swift Amy J, Syvänen Ann-Christine, Tuomi Tiinamaija, Tuomilehto Jaakko, Tönjes Anke, Valle Timo T, Williams Gordon H, Lind Lars, Barroso Inês, Quertermous Thomas, Walker Mark, Wareham Nicholas J, Meigs James B, McCarthy Mark I, Groop Leif, Watanabe Richard M, Florez Jose C
Abstract excerpt
OBJECTIVE Recent genome-wide association studies have revealed loci associated with glucose and insulin-related traits. We aimed to characterize 19 such loci using detailed measures of insulin processing, secretion, and sensitivity to help elucidate their role in regulation of glucose control, insulin secretion and/or action. RESEARCH DESIGN AND METHODS We investigated associations of loci identified by the...
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