Article

Integrative multi-region molecular profiling of primary prostate cancer with synchronous lymph node metastasis to characterize the biologically dominant clone

2023-04-20

Abstract excerpt

<title>Abstract</title> <p>Localized prostate cancer is composed of multiple spatially distinct tumors with significant inter- and intra-tumoral molecular heterogeneity. This genomic diversity gives rise to many competing subclones that may drive the biological trajectory of the disease. Previous large scale sequencing efforts have focused on the evolutionary process of metastatic prostate cancer, revealing a pot...

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Literature Corpus work: 63e10703-57d1-57db-b510-0071eb22f053
DOI: 10.21203/rs.3.rs-2786222/v1

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