Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy

8 Oct 2020

Abstract excerpt

The evolutionary progression from primary to metastatic prostate cancer is largely uncharted, and the implications for liquid biopsy are unexplored. We infer detailed reconstructions of tumor phylogenies in ten prostate cancer patients with fatal disease, and investigate them in conjunction with histopathology and tumor DNA extracted from blood and cerebrospinal fluid. Substantial evolution occurs within the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Prostate Cancer Diagnosis and Treatment
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33033260
DOI: 10.1038/s41467-020-18843-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsyPMID 33033260Read ↗

Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer.Semantic proximity Read ↗

The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression.Semantic proximity Read ↗

A Systematic Review of Prostate Cancer Heterogeneity: Understanding the Clonal Ancestry of Multifocal Disease.Semantic proximity Read ↗

Tracking the clonal origin of lethal prostate cancer.Semantic proximity Read ↗

Clonal Evolution and Transcriptional Plasticity Shape Metastatic Dissemination Routes in Prostate CancerSemantic proximity Read ↗

Somatic mutations reveal complex metastatic seeding from multifocal primary prostate cancer.Semantic proximity Read ↗

Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole genome sequencing with histopathological featuresSemantic proximity Read ↗

Divergent Clonal Evolution and Early Dissemination Promote Genetic Heterogeneity of Metastases in Castration-Resistant Prostate Cancer.Semantic proximity Read ↗

Clonality of localized and metastatic prostate cancer.Semantic proximity Read ↗

Integrative multi-region molecular profiling of primary prostate cancer with synchronous lymph node metastasis to characterize the biologically dominant cloneSemantic proximity Read ↗

Single-cell genomic analysis of cancer cells from one treatment-naïve patient with metastatic prostate cancer.Semantic proximity Read ↗

Unpacking circulating tumor DNA lends insight into prostate cancer biology and the clonal dynamics of metastasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.