Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion.

The Journal of biological chemistry - 4 Mar 2016

Dong Ke, Yan Qingshang, Lu Ming, Wan Laxiang, Hu Haiyan, Guo Junhua, Boulpaep Emile, Wang WenHui, Giebisch Gerhard, Hebert Steven C, Wang Tong

Abstract excerpt

Romk knock-out mice show a similar phenotype to Bartter syndrome of salt wasting and dehydration due to reduced Na-K-2Cl-cotransporter activity. At least three ROMK isoforms have been identified in the kidney; however, unique functions of any of the isoforms in nephron segments are still poorly understood. We have generated a mouse deficient only in Romk1 by selective deletion of the Romk1-specific first exon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bartter Syndrome
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Ion Channel Gating

Share to Kidney Tubules, Collecting

Share to Potassium

Share to Potassium Channels, Inwardly Rectifying

Share to Sodium

Source

Open in PubMed Open full text

Identifiers

PMID: 26728465
DOI: 10.1074/jbc.M115.707877
PMCID: PMC4777858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion.PMID 26728465Read ↗

Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice.Semantic proximity Read ↗

Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome.Semantic proximity Read ↗

Heterozygous disruption of renal outer medullary potassium channel in rats is associated with reduced blood pressure.Semantic proximity Read ↗

Urinary bladder hypertrophy characteristic of male ROMK Bartter's mice does not occur in female mice.Semantic proximity Read ↗

Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK.Semantic proximity Read ↗

Bartter Syndromes and Other Salt-Losing TubulopathiesSemantic proximity Read ↗

Mutations in the ROMK gene in antenatal Bartter syndrome are associated with impaired K+ channel function.Semantic proximity Read ↗

Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K+ intake on ROMK channel in the distal convoluted tubule.Semantic proximity Read ↗

A Bartter's syndrome mutation of ROMK1 exerts dominant negative effects on K(+) conductance.Semantic proximity Read ↗

New roles for renal potassium channels.Semantic proximity Read ↗

The Urinary Excretion of Uromodulin is Regulated by the Potassium Channel ROMK.Semantic proximity Read ↗

Loop disorders: insights derived from defined genotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.