Article
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2007
Ring Aaron M, Cheng Sam X, Leng Qiang, Kahle Kristopher T, Rinehart Jesse, Lalioti Maria D, Volkman Heather M, Wilson Frederick H, Hebert Steven C, Lifton Richard P
Abstract excerpt
Homeostasis of intravascular volume, Na(+), Cl(-), and K(+) is interdependent and determined by the coordinated activities of structurally diverse mediators in the distal nephron and the distal colon. The behavior of these flux pathways is regulated by the renin-angiotensin-aldosterone system; however, the mechanisms that allow independent modulation of individual elements have been obscure. Previous work has...
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