Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4PHAII mice.

American journal of physiology. Renal physiology - 1 Apr 2017

Zhang Chengbiao, Wang Lijun, Su Xiao-Tong, Zhang Junhui, Lin Dao-Hong, Wang Wen-Hui

Abstract excerpt

Mice transgenic for genomic segments harboring PHAII (pseudohypoaldosteronism type II) mutant Wnk4 (with-No-Lysine kinase 4) (TgWnk4PHAII) have hyperkalemia which is currently believed to be the result of high activity of Na-Cl cotransporter (NCC). This leads to decreasing Na+ delivery to the distal nephron segment including late distal convoluted tubule (DCT) and connecting tubule (CNT). Since epithelial Na+...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down-Regulation
Share to Epithelial Sodium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperkalemia

Share to Kidney Tubules, Distal

Share to Membrane Potentials

Share to Potassium

Share to Potassium Channels, Inwardly Rectifying

Share to Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 28365586
DOI: 10.1152/ajprenal.00420.2016
PMCID: PMC5407067

Genes

DCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4PHAII mice.PMID 28365586Read ↗

Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule.Semantic proximity Read ↗

Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K+ intake on ROMK channel in the distal convoluted tubule.Semantic proximity Read ↗

Mechanism of impaired potassium transport in pseudohypoaldosteronism (type II).Semantic proximity Read ↗

WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.Semantic proximity Read ↗

WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.Semantic proximity Read ↗

WNK kinases regulate thiazide-sensitive Na-Cl cotransport.Semantic proximity Read ↗

Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse modelsSemantic proximity Read ↗

An inducible transgenic mouse model for familial hypertension with hyperkalaemia (Gordon's syndrome or pseudohypoaldosteronism type II).Semantic proximity Read ↗

WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.Semantic proximity Read ↗

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.Semantic proximity Read ↗

Severe hyperkalemia is rescued by low-potassium diet in renal βENaC-deficient mice.Semantic proximity Read ↗

SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.