Article
WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).
The Journal of physiology - 1 Mar 2006
Leng Qiang, Kahle Kristopher T, Rinehart Jesse, MacGregor Gordon G, Wilson Frederick H, Canessa Cecilia M, Lifton Richard P, Hebert Steven C
Abstract excerpt
The serine-threonine kinase WNK3 modulates Cl- transport into and out of cells through its regulation of SLC12A cation/Cl- cotransporters, implicating it as (one of) the long-sought Cl-/volume-sensitive kinase(s). Integrators in homeostatic systems regulate structurally diverse but functionally coupled elements. For example, the related kinase WNK4 regulates the Na-Cl co-transporter (NCC), paracellular Cl- flux,...
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