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Article

Mechanism of impaired potassium transport in pseudohypoaldosteronism (type II).

American journal of physiology. Renal physiology - 1 Jul 2026

Lessa Lucília M A, Wan Laxiang, Yan Qingshang, Shen Elizabeth, Malnic Gerhard, Giebisch Gerhard, Wang Tong

Abstract excerpt

Pseudohypoaldosteronism type II (PHAII), also known as Gordon syndrome, is an autosomal-dominant disorder caused by mutations in with-no-lysine kinase 4 (WNK4) and is characterized by increased renal sodium chloride (NaCl) reabsorption and impaired potassium (K+) secretion. We examined the relative contributions of renal outer medullary K+ (ROMK) channels and large-conductance Ca2+-activated K+ (BK; Maxi-K)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42258358
DOI: 10.1152/ajprenal.00046.2026

Genes

WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Mechanism of impaired potassium transport in pseudohypoaldosteronism (type II).PMID 42258358Read ↗

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