Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The renal TRPV4 channel is essential for adaptation to increased dietary potassium.

Kidney international - 1 Jun 2017

Mamenko Mykola V, Boukelmoune Nabila, Tomilin Viktor N, Zaika Oleg L, Jensen V Behrana, O'Neil Roger G, Pochynyuk Oleh M

Abstract excerpt

To maintain potassium homeostasis, kidneys exert flow-dependent potassium secretion to facilitate kaliuresis in response to elevated dietary potassium intake. This process involves stimulation of calcium-activated large conductance maxi-K (BK) channels in the distal nephron, namely the connecting tubule and the collecting duct. Recent evidence suggests that the TRPV4 channel is a critical determinant of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeostasis

Share to Hyperkalemia

Share to Kidney Tubules

Share to Large-Conductance Calcium-Activated Potassium Channels

Share to Receptors, Mineralocorticoid

Share to TRPV Cation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 28187982
DOI: 10.1016/j.kint.2016.12.010
PMCID: PMC5429991

Genes

TRPV4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The renal TRPV4 channel is essential for adaptation to increased dietary potassium.PMID 28187982Read ↗

The role of the BK channel in potassium homeostasis and flow-induced renal potassium excretion.Semantic proximity Read ↗

TRPV5: a Ca(2+) channel for the fine-tuning of Ca(2+) reabsorption.Semantic proximity Read ↗

Basolateral membrane K+channels in renal epithelial cellsSemantic proximity Read ↗

Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K+ intake on ROMK channel in the distal convoluted tubule.Semantic proximity Read ↗

Increased severity of chronic kidney disease in response to high potassium intake is dependent on mineralocorticoid receptor activationSemantic proximity Read ↗

The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis.Semantic proximity Read ↗

The role of transient receptor potential channels in kidney disease.Semantic proximity Read ↗

New roles for renal potassium channels.Semantic proximity Read ↗

WNK kinases influence TRPV4 channel function and localization.Semantic proximity Read ↗

WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.Semantic proximity Read ↗

In vivo treatment with calcilytic of CaSR knock-in mice ameliorates renal phenotype reversing downregulation of the vasopressin-AQP2 pathway.Semantic proximity Read ↗

Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.