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Article

Stabilization of warfarin-binding pocket of VKORC1 and VKORL1 by a peripheral region determines their different sensitivity to warfarin inhibition.

Journal of thrombosis and haemostasis : JTH - 1 Jun 2018

Shen G, Li S, Cui W, Liu S, Liu Q, Yang Y, Gross M, Li W

Abstract excerpt

Essentials VKORL1 and VKORC1 have a similar overall structure and warfarin-binding pocket. A peripheral region stabilizing this pocket controls warfarin sensitivity of the VKOR paralogs. A human single nucleotide polymorphism in this region renders VKORL1 sensitive to warfarin. A group of warfarin-resistant mutations in VKORC1 acts by disrupting peripheral interactions. SUMMARY: Background The human genome...

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Share to Anticoagulants
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oxidation-Reduction

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Share to Vitamin K Epoxide Reductases

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Source

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Identifiers

PMID: 29665197
DOI: 10.1111/jth.14127
PMCID: PMC6231229

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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