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Article

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact.

eLife - 1 Sept 2020

Chiasson Melissa A, Rollins Nathan J, Stephany Jason J, Sitko Katherine A, Matreyek Kenneth A, Verby Marta, Sun Song, Roth Frederick P, DeSloover Daniel, Marks Debora S, Rettie Allan E, Fowler Douglas M

Abstract excerpt

Vitamin K epoxide reductase (VKOR) drives the vitamin K cycle, activating vitamin K-dependent blood clotting factors. VKOR is also the target of the widely used anticoagulant drug, warfarin. Despite VKOR's pivotal role in coagulation, its structure and active site remain poorly understood. In addition, VKOR variants can cause vitamin K-dependent clotting factor deficiency or alter warfarin response. Here, we used...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32870157
DOI: 10.7554/eLife.58026
PMCID: PMC7462613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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