Article
VKORC1 and the vitamin K cycle.
Vitamins and hormones - 1 Jan 2008
Garcia Andrea A, Reitsma Pieter H
Abstract excerpt
Vitamin K epoxide, a product of gamma-carboxylation, must be rapidly recycled to its reduced form before it can be reused. The set of sequential reactions that guarantees vitamin K recycling is known as the vitamin K cycle. This review is focused on biochemical and genetic aspects of a recently characterized key enzyme of the cycle named vitamin K epoxide reductase complex subunit 1 (VKORC1). This 163-amino acid...
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