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Article

Warfarin resistance associated with genetic polymorphism of VKORC1: linking clinical response to molecular mechanism using computational modeling.

Pharmacogenetics and genomics - 1 Jan 2016

Lewis Benjamin C, Nair Pramod C, Heran Subash S, Somogyi Andrew A, Bowden Jeffrey J, Doogue Matthew P, Miners John O

Abstract excerpt

The variable response to warfarin treatment often has a genetic basis. A protein homology model of human vitamin K epoxide reductase, subunit 1 (VKORC1), was generated to elucidate the mechanism of warfarin resistance observed in a patient with the Val66Met mutation. The VKORC1 homology model comprises four transmembrane (TM) helical domains and a half helical lid domain. Cys132 and Cys135, located in the...

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Source

Identifiers

PMID: 26513304
DOI: 10.1097/FPC.0000000000000184

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Warfarin resistance associated with genetic polymorphism of VKORC1: linking clinical response to molecular mechanism using computational modeling.PMID 26513304Read ↗

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