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Article

Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2011

Watzka M, Geisen C, Bevans C G, Sittinger K, Spohn G, Rost S, Seifried E, Müller C R, Oldenburg J

Abstract excerpt

BACKGROUND: Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) is the molecular target of oral anticoagulants. Mutations in VKORC1 cause partial or total coumarin resistance. OBJECTIVES: To identify new VKORC1 oral anticoagulant (OAC) resistance (OACR) mutations and compare the severity of patient phenotypes across different mutations and prescribed OAC drugs. PATIENTS/METHODS: Six hundred and twenty-six...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20946155
DOI: 10.1111/j.1538-7836.2010.04095.x

Genes

VKORC1

Provenance

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Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment.PMID 20946155Read ↗

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