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Article

Pharmacodynamic resistance to warfarin is associated with nucleotide substitutions in VKORC1.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2008

Harrington D J, Gorska R, Wheeler R, Davidson S, Murden S, Morse C, Shearer M J, Mumford A D

Abstract excerpt

BACKGROUND: Vitamin K epoxide reductase subunit 1 (VKORC1) is the molecular target of coumarin anticoagulants and mutations in VKORC1 have been identified previously in individuals who required high warfarin doses. OBJECTIVE: Detailed characterization of the relationship between variation in VKORC1 and the warfarin resistance phenotype. PATIENTS AND METHODS: Serum warfarin concentration and coagulation parameters...

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Source

Identifiers

PMID: 18680536
DOI: 10.1111/j.1538-7836.2008.03116.x

Genes

VKORC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pharmacodynamic resistance to warfarin is associated with nucleotide substitutions in VKORC1.PMID 18680536Read ↗

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