Article

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

2020-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Vitamin K epoxide reductase (VKOR) drives the vitamin K cycle, activating vitamin K-dependent blood clotting factors. VKOR is also the target of the widely used anticoagulant drug, warfarin Despite VKOR’s pivotal role in coagulation, its structure and active site remain poorly understood. In addition, VKOR variants can cause vitamin K-dependent clotting factor deficiency 2 or alter warfarin resp...

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Literature Corpus work: eb8da566-bf7f-5c38-8739-a683fbf19d19
DOI: 10.1101/2020.05.10.087312

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