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Article

A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance

16 Nov 2006

Abstract excerpt

CYP2C9 and VKORC1 genetic variants are associated with low and intermediate warfarin dose requirements, but markers of high doses are less well characterized. We analyzed the VKORC1 coding sequence and known CYP2C9 and VKORC1 polymorphisms in 15 selected warfarin-resistant (dose, 80 to 185 mg/wk) and 8 warfarin-sensitive patients (7 to 13 mg/wk) and 99 unselected controls (8 to 105 mg/wk). We identified a coding...

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PMID: 17110455
DOI: 10.1182/blood-2006-08-038984

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