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Article

Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2013

Tie J-K, Jin D-Y, Tie K, Stafford D W

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms in the vitamin K epoxide reductase (VKOR) gene have been successfully used for warfarin dosage prediction. However, warfarin resistance studies of naturally occurring VKOR mutants do not correlate with their clinical phenotype. This discrepancy presumably arises because the in vitro VKOR activity assay is performed under artificial conditions using the non-physiological...

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Identifiers

PMID: 23710884
DOI: 10.1111/jth.12306
PMCID: PMC3745541

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