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Article

Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins.

Nature genetics - 1 Jan 2015

Buil Alfonso, Brown Andrew Anand, Lappalainen Tuuli, Viñuela Ana, Davies Matthew N, Zheng Hou-Feng, Richards J Brent, Glass Daniel, Small Kerrin S, Durbin Richard, Spector Timothy D, Dermitzakis Emmanouil T

Abstract excerpt

Understanding the genetic architecture of gene expression is an intermediate step in understanding the genetic architecture of complex diseases. RNA sequencing technologies have improved the quantification of gene expression and allow measurement of allele-specific expression (ASE). ASE is hypothesized to result from the direct effect of cis regulatory variants, but a proper estimation of the causes of ASE has...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Twins, Dizygotic

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Source

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Identifiers

PMID: 25436857
DOI: 10.1038/ng.3162
PMCID: PMC4643454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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