Article
Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression.
PLoS genetics - 1 Jan 2012
Fu Jingyuan, Wolfs Marcel G M, Deelen Patrick, Westra Harm-Jan, Fehrmann Rudolf S N, Te Meerman Gerard J, Buurman Wim A, Rensen Sander S M, Groen Harry J M, Weersma Rinse K, van den Berg Leonard H, Veldink Jan, Ophoff Roel A, Snieder Harold, van Heel David, Jansen Ritsert C, Hofker Marten H, Wijmenga Cisca, Franke Lude
Abstract excerpt
It is known that genetic variants can affect gene expression, but it is not yet completely clear through what mechanisms genetic variation mediate this expression. We therefore compared the cis-effect of single nucleotide polymorphisms (SNPs) on gene expression between blood samples from 1,240 human subjects and four primary non-blood tissues (liver, subcutaneous, and visceral adipose tissue and skeletal muscle)...
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