Article
Allele-specific expression reveals interactions between genetic variation and environment.
Nature methods - 1 Jul 2017
Knowles David A, Davis Joe R, Edgington Hilary, Raj Anil, Favé Marie-Julie, Zhu Xiaowei, Potash James B, Weissman Myrna M, Shi Jianxin, Levinson Douglas F, Awadalla Philip, Mostafavi Sara, Montgomery Stephen B, Battle Alexis
Abstract excerpt
Identifying interactions between genetics and the environment (GxE) remains challenging. We have developed EAGLE, a hierarchical Bayesian model for identifying GxE interactions based on associations between environmental variables and allele-specific expression. Combining whole-blood RNA-seq with extensive environmental annotations collected from 922 human individuals, we identified 35 GxE interactions, compared...
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