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Article

Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development.

Neuron - 17 Nov 2011

Singh Karun K, De Rienzo Gianluca, Drane Laurel, Mao Yingwei, Flood Zachary, Madison Jon, Ferreira Manuel, Bergen Sarah, King Cillian, Sklar Pamela, Sive Hazel, Tsai Li-Huei

Abstract excerpt

Disrupted in Schizophrenia-1 (DISC1) is a candidate gene for psychiatric disorders and has many roles during brain development. Common DISC1 polymorphisms (variants) are associated with neuropsychiatric phenotypes including altered cognition, brain structure, and function; however, it is unknown how this occurs. Here, we demonstrate using mouse, zebrafish, and human model systems that DISC1 variants are loss of...

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Identifiers

PMID: 22099458
DOI: 10.1016/j.neuron.2011.09.030
PMCID: PMC3387684

Genes

DISC1

Variants

Provenance

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