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Article

A rare non-synonymous c.102C>G SNP in the IFNB1 gene might be a risk factor for cerebral malaria in Indian populations.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2013

Jha Aditya Nath, Singh Vipin Kumar, Singh Rajender, Pati Sudhanshu S, Patra Pradeep K, Singh Lalji, Thangaraj Kumarasamy

Abstract excerpt

Interferon beta1 (IFNB1) is a type I interferon that is mainly known for its antiviral activity, but it also regulates a number of anti-inflammatory and immunomodulatory functions. Studies on mouse models of cerebral malaria have established that IFNB1 regulates severe malaria pathogenesis and increases overall survival against malaria. It down-regulates pro-inflammatory cytokines: TNF, IFNG and ICAM-1, resulting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23333334
DOI: 10.1016/j.meegid.2012.12.029

Genes

IFNB1
IFNG
TNF

Variants

rs139262191

Provenance

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