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Article

Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.

Nature chemical biology - 1 May 2018

Dong Cheng, Zhang Heng, Li Li, Tempel Wolfram, Loppnau Peter, Min Jinrong

Abstract excerpt

The N-end rule pathway senses the N-terminal destabilizing residues of degradation substrates for the ubiquitin-proteasome system, whose integrity shields against various human syndromes including cancer and cardiovascular diseases. GID4, a subunit of the ubiquitin ligase GID complex, has been recently identified as the N-recognin of the new branch of the N-end rule pathway responsible for recognizing substrates...

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Source

Identifiers

PMID: 29632410
DOI: 10.1038/s41589-018-0036-1

Genes

GID4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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