Article

Structure of E3 ligase E6AP with a novel proteasome-binding site provided by substrate receptor hRpn10

2019-10-09

Abstract excerpt

Regulated proteolysis by the proteasome involves ∼800 enzymes for substrate modification with ubiquitin, of which ∼600 are E3 ligases. We report here that E6AP/UBE3A is distinguished from other ubiquitin E3 ligases by having a 12 nM binding site at the proteasome contributed by substrate receptor hRpn10/PSMD4/S5a. Intrinsically disordered by itself, and previously uncharacterized, this domain in hRpn10 locks into...

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Literature Corpus work: 5ca2dbab-e783-59a3-8986-3720e3ffe066
DOI: 10.1101/797027

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