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Article

A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.

Molecular and cellular biology - 1 Aug 2005

Tasaki Takafumi, Mulder Lubbertus C F, Iwamatsu Akihiro, Lee Min Jae, Davydov Ilia V, Varshavsky Alexander, Muesing Mark, Kwon Yong Tae

Abstract excerpt

A subset of proteins targeted by the N-end rule pathway bear degradation signals called N-degrons, whose determinants include destabilizing N-terminal residues. Our previous work identified mouse UBR1 and UBR2 as E3 ubiquitin ligases that recognize N-degrons. Such E3s are called N-recognins. We report here that while double-mutant UBR1(-/-) UBR2(-/-) mice die as early embryos, the rescued UBR1(-/-) UBR2(-/-)...

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Source

Open in PubMed Open full text

Identifiers

PMID: 16055722
DOI: 10.1128/MCB.25.16.7120-7136.2005
PMCID: PMC1190250

Genes

UBR1
UBR2
UBR4
UBR5
UBR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.PMID 16055722Read ↗

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