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Article

Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML).

Journal of translational medicine - 10 Apr 2018

Zhu Ke-Wei, Chen Peng, Zhang Dao-Yu, Yan Han, Liu Han, Cen Li-Na, Liu Yan-Ling, Cao Shan, Zhou Gan, Zeng Hui, Chen Shu-Ping, Zhao Xie-Lan, Chen Xiao-Ping

Abstract excerpt

BACKGROUND: Cytarabine arabinoside (Ara-C) has been the core of chemotherapy for adult acute myeloid leukemia (AML). Ara-C undergoes a three-step phosphorylation into the active metabolite Ara-C triphosphosphate (ara-CTP). Several enzymes are involved directly or indirectly in either the formation or detoxification of ara-CTP. METHODS: A total of 12 eQTL (expression Quantitative Trait Loci) single nucleotide...

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Share to Cytarabine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 29631596
DOI: 10.1186/s12967-018-1463-1
PMCID: PMC5892020

Genes

NME2
NME1
RRM1
SAMHD1
CMPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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