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Article

Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients.

Journal of translational medicine - 15 Nov 2017

Cao Hai-Xia, Miao Chao-Feng, Yan Liang, Tang Ping, Zhang Li-Rong, Sun Ling

Abstract excerpt

BACKGROUND: Gene polymorphisms at microRNA-binding sites (poly-miRTS) may affect gene transcription and expression through miRNA regulation, which is associated with cancer susceptibility, sensitivity to chemotherapy and prognosis. This study investigated the association between poly-miRTS of Ara-C/anthracycline metabolic pathways genes and the outcome of acute myeloid leukemia (AML) in Chinese patients after...

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Share to Anthracyclines
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Inactivation, Metabolic

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 29141648
DOI: 10.1186/s12967-017-1339-9
PMCID: PMC5688732

Genes

ABCC1
CBR1
DCTD
RRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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