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Article

Comprehensive Ara-C SNP score predicts leukemic cell intracellular ara-CTP levels in pediatric acute myeloid leukemia patients.

Pharmacogenomics - 1 Sept 2018

Elsayed Abdelrahman H, Cao Xueyuan, Crews Kristine R, Gandhi Varsha, Plunkett William, Rubnitz Jeffrey E, Ribeiro Raul C, Pounds Stanley B, Lamba Jatinder K

Abstract excerpt

AIM: Cytarabine (Ara-C), a mainstay of acute myeloid leukemia (AML) treatment, is a prodrug requiring activation to ara-CTP for its antileukemic activity. Aim of this study was to evaluate impact of genetic variants in the key genes involved in ara-C metabolism on the leukemic cell intracellular levels of ara-CTP. METHOD: We investigated SNPs in 14 ara-C metabolic-pathway genes, for association with intracellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30088438
DOI: 10.2217/pgs-2018-0086
PMCID: PMC6219441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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