Article
Single nucleotide polymorphisms of cytarabine metabolic genes influence clinical outcome in acute myeloid leukemia patients receiving high-dose cytarabine therapy.
International journal of hematology - 1 Jun 2015
Amaki Jun, Onizuka Makoto, Ohmachi Ken, Aoyama Yasuyuki, Hara Ryujiro, Ichiki Akifumi, Kawai Hidetsugu, Sato Ai, Miyamoto Mitsuki, Toyosaki Masako, Machida Shinichiro, Kojima Minoru, Shirasugi Yukari, Kawada Hiroshi, Ogawa Yoshiaki, Ando Kiyoshi
Abstract excerpt
Cytarabine arabinoside (Ara-C) is the most important agent for treating acute myeloid leukemia (AML). Here, we genotyped 11 single nucleotide polymorphisms (SNPs) of seven Ara-C metabolism-related genes in 39 AML patients who had received high-dose Ara-C as a single-agent treatment. Univariate analysis identified three SNPs that were significantly associated with shorter time-to-relapse (TTR): CTPS rs12144160 GG...
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