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Article

Association of polymorphisms of cytosine arabinoside-metabolizing enzyme gene with therapeutic efficacy for acute myeloid leukemia.

Chinese medical journal - 1 Jun 2012

Xu Pei-Pei, Chen Bao-An, Feng Ji-Feng, Cheng Lu, Xia Guo-Hua, Li Yu-Feng, Qian Jun, Ding Jia-Hua, Lu Zu-Hong, Wang Xue-Mei, Xu Ke, Schultz Margaret

Abstract excerpt

BACKGROUND: The cytosine arabinoside (Ara-C)-based chemotherapy is the major remedial measure for acute myeloid leukemia (AML). Deoxycytidine kinase (DCK) and cytidine deaminase (CDA) are the key enzymes in the metabolism of Ara-C. Many single nucleotide polymorphisms (SNPs) and haplotypes of DCK and CDA, which contribute to susceptibility to Ara-C, have been identified in Africans and Europeans. However, there...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22884143

Genes

CDA
DCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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