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Article

Effect of NME2 and SAMHD1 genetic polymorphisms involved in Ara-C metabolism on the response to induction chemotherapy in adult acute myeloid leukemia.

Journal of the Egyptian National Cancer Institute - 28 Apr 2025

Fouad Lamiaa Ahmed, Elsayed Ghada Mohamed, El-Gammal Mosaad M, Rasekh Eman Omar, Ibrahim Sarah Khaled, Ragab Eman Ali, Rashidi Fatma B

Abstract excerpt

BACKGROUND: Cytarabine is a prodrug which is activated to cytarabine triphosphate (Ara-CTP) through a series of phosphorylation steps. For considerable leukemic cell death, high level of Ara-CTP is required. Sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) and Nucleotide diphosphate kinase-2 (NME2) are genes involved in Ara-CTP metabolism. To best of our knowledge, there are no...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Share to SAM Domain and HD Domain-Containing Protein 1

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Source

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Identifiers

PMID: 40289230
DOI: 10.1186/s43046-025-00272-4
PMCID: PMC13313442

Genes

SAMHD1
NME2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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