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Article

Influence of cytarabine metabolic pathway polymorphisms in acute myeloid leukemia induction treatment.

Leukemia & lymphoma - 1 Dec 2017

Megías-Vericat Juan Eduardo, Montesinos Pau, Herrero María José, Moscardó Federico, Bosó Virginia, Martínez-Cuadrón David, Rojas Luis, Rodríguez-Veiga Rebeca, Boluda Blanca, Sendra Luis, Cervera José, Poveda José Luis, Sanz Miguel Ángel, Aliño Salvador F

Abstract excerpt

Cytarabine is considered the most effective chemotherapeutic option in acute myeloid leukemia (AML). The impact of 10 polymorphisms in cytarabine metabolic pathway genes were evaluated in 225 adult de novo AML patients. Variant alleles of DCK rs2306744 and CDA rs602950 showed higher complete remission (p = .024, p = .045), with lower survival rates for variant alleles of CDA rs2072671 (p = .015, p = .045,...

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Topics

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Share to Antimetabolites, Antineoplastic
Share to Cytarabine
Share to Kaplan-Meier Estimate
Share to Leukemia, Myeloid, Acute
Share to Metabolic Networks and Pathways
Share to Pharmacogenomic Variants
Share to Prognosis
Share to Remission Induction

Source

Identifiers

PMID: 28573946
DOI: 10.1080/10428194.2017.1323267

Genes

CDA
DCK
RRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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