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Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition

27 Feb 2014

Abstract excerpt

INTRODUCTION: Tau pathology is associated with a number of age-related neurodegenerative disorders. Few treatments have been demonstrated to diminish the impact of tau pathology in mouse models and none are yet effective in humans. Histone deacetylase 6 (HDAC6) is an enzyme that removes acetyl groups from cytoplasmic proteins, rather than nuclear histones. Its substrates include tubulin, heat shock protein 90 and...

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PMID: 24576665
DOI: 10.1186/alzrt241

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