Article
Somatic mutation, copy number and transcriptomic profiles of primary and matched metastatic estrogen receptor-positive breast cancers.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Oct 2016
Fumagalli D, Wilson T R, Salgado R, Lu X, Yu J, O'Brien C, Walter K, Huw L Y, Criscitiello C, Laios I, Jose V, Brown D N, Rothé F, Maetens M, Zardavas D, Savas P, Larsimont D, Piccart-Gebhart M J, Michiels S, Lackner M R, Sotiriou C, Loi S
Abstract excerpt
BACKGROUND: Estrogen receptor-positive (ER+) breast cancers (BCs) constitute the most frequent BC subtype. The molecular landscape of ER+ relapsed disease is not well characterized. In this study, we aimed to describe the genomic evolution between primary (P) and matched metastatic (M) ER+ BCs after failure of adjuvant therapy. MATERIALS AND METHODS: A total of 182 ER+ metastatic BC patients with long-term...
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