Article
Genomics alterations of metastatic and primary tissues across 15 cancer types.
Scientific reports - 16 Oct 2017
Liu Gang, Zhan Xiaohui, Dong Chuanpeng, Liu Lei
Abstract excerpt
Metastasis is an important event for cancer evolution and prognosis. In this article, we analyzed the differences in genomic alterations between primary and metastatic tissues at hotspot regions in 15 cancer types and 10,456 samples. Differential somatic mutations at the amino acid, protein domain and gene levels, mutational exclusiveness, and copy number variations were identified in these cancers, while no...
Topics
- DNA Copy Number Variations
- Gene Expression Regulation, Neoplastic
- High-Throughput Nucleotide Sequencing
- Humans
- Mutation
- Neoplasm Metastasis